Seplite

4-Hydroxymethyl-phenylacetamidomethyl resin PAM resin has become the most widely used resin in Boc chemistry peptide synthesis. It has greater acid stability than Merrifield resin, making it suitable for synthesizing medium and large peptides, such as DNA binding polyamines, human matrix Gla protein(MGP), Kappa-casein. The first carboxylic acid is attached to PAM resin  using an activating agent such as DCC and DMAP. These conditions can lead to partial epimerization of the amino acids, so HOBt is normally added to reduce racemization. Product No Particle size （mesh） Loading （mmol/g resin） LXSS11-1-1401 100-200; 200-400 0.4-0.8 LXSS11-1-1402 100-200; 200-400 0.8-1.2

SEPLITE ® Weak Base Anion Resin The Weak Base Anion Exchange Resin with primary, secondary, tertiary amine or mixed amine group as active functional groups show different strengths of alkalinity. Most weak Base Anion Exchange Resins with mixed amine group equiped a extremely high operating capacity with the ability to remove both strong and weak acids from solution. There are two kinds of weak base anion exchange resins, Gel type and Macroporous type, which have acrylic backbone, styrene backbone or mixed backbone. Weak base anion exchange resins are more chemically stable and higher resistant to organic fouling than strong base anions. The weak base anion exchange resin  is easier to regenerate than the strong base resin, and can be efficiently regenerated with a small amount of sodium hydroxide. Weak base anion exchange resins are commonly used in pharmaceutical, food engineering, and chemical engineering, such as the removal of mineral acid, organic acids and other

The Fmoc method is a new method for solid phase synthesis of peptides developed by Carpino and Hart based on the Boc method. The fundamental difference between the Fmoc  ltd   /t-Bu(9-fluorenylmethoxycarbonyl/tert-butoxy) strategy and the Boc/Bzl strategy is the use of alkali-removable Fmoc is a protecting group for α-amino group, the side chain is protected by t-Bu which can be removed by TFA, and the solid phase carrier Wang resin with acid-sensitive linking arm is used, and the final step of the synthesis is removed by TFA. Han Xiang et al. successfully synthesized the 32-peptide thymosin α 1 by Fm oc solid phase method, starting from Fm oc-Asn(Trt)-W angResin, Boc protecting the side chain amino group of Lys, and tert-butyl ester group (O-t-Bu Protecting the side chain carboxyl group of Asp and Glu, t -Bu protects the side chain hydroxyl group of Ser and Thr, and trityl group (Trt) protects the side chain amide group of Asn, and the total synthesis yield is 33.2%, and the puri

SEPLITE ® S trong B ase A nion R esin The Strong Base Anion Exchange Resin (   SBA resin ) is the type of ion exchange resin with functional group of quaternary ammonium, which is strongly alkaline and dissociates just like NaOH and KOH. In chemical structure, there are two types of strong base anion exchange resin with different alkalinity strengths, Type Ⅰ with a trimethyl ammonium group, Type Ⅱ with a dimethylethanol ammonium group. Type Ⅰ shows a higher alkaline than Type Ⅱ. Compared with type 1 strong base anion, this resin is more suitable for applications needing good rinsing performance and excellent regeneration efficiency. The strong base anion exchanger  shows an excellent physical and chemical stability, which is capable of exchanging the different anion under a wide range of pH. The Strong Base Anion Exchange Resin is mainly used in water treatment, to produce high purity demineralized water, making use of the ability to adsorb anions strongly. Typical

SEPLITE ® Strong Acid Cation Exchange Resin The Strong Acid Cation Exchange Resin (   SAC   resin ) is the type of ion exchange resin with functional group of sulfonic acid The strongly acidic ion exchange resin  ha s  two types, the gel and the macroporous type. The macroporous strong acid cation exchange resin shows an excellent dynamic characteristics. The gel type has excellent properties for industrial water softening and demineralization application. It has standard crosslinkage, which is usually used in mixed bed; the higher crosslinkage resin shows a longer operating life, and used in regenerable mixed bed. The Strong Acid Cation Exchange Resin shows an excellent physical and chemical stability, which operates at any pH(0-14), and are relatively stable to temperture, even in high temperatures of 100-120℃. The Strong Acid Cation Exchange Resin is applied in a wide variety of fields including water purification, water softening, waste water treatment, purificatio

Separation Technique Based on Ion Exchange & Adsorption S tevioside extraction and purification   is mainly extracted from the roots and leaves of stevia leaves, with the highest content of stevioside in leaves. Its sweet taste mainly consists of stevioside A, B, C, D, E. Stevioside can be extracted with water, and after clarification and crystallization, extracts of different purities can be obtained. Stevioside is 250-450 times sweeter than sucrose, but because of the presence of stevioside A, it has a distinct bitter taste and astringency. Our technology in stevioside extraction is based on the principle of ion exchange and adsorption, using a series supporting separation system to achieve extraction, decolorization, demineralization, purification and other important steps. Our technology has achieved great success in China. Sunresin has conducted in-depth research in the field of stevia refining. Sunresin once hosted the China Stevia Industry Technical Exchange

Peptide Synthesis Resins Since Solid Phase Peptide Synthesis (we can also call it spps resins )  was first proposed by Robert Bruce Merrifield, the method of synthetic peptides became more popular than liquid phase peptide synthesis because of high efficiency. This method could assemble a peptide chain rapidly through successive reactions of amino acid derivatives on an insoluble support. The original peptide antibiotics are also biosynthesized and extracted from the culture of polymyxa or aeruginosa. Another synthetic method of peptides is chemical synthesis, which is divided into liquid phase chemical synthesis and solid phase chemical synthesis. The liquid phase method is mainly used for the synthesis of short peptides. The solid phase synthesis method can be used to prepare long-chain peptides, cyclic peptides, and complex. Peptide. The solid phase method is divided into a Boc method and an Fmoc method. It requires the solid phase synthesis of the carrier to achieve the gr

9-Fmoc-Aminoxanthen-3-yloxy-polystyrene resin A hyper acid-labile linker or the Fmoc SPPS of protected amides via mild 1% TFA cleavage. The sieber amide resin  can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides. This resin has also been employed to produce protected peptide fragments in wich the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester. Product No Particle size（mesh） Loading（mmol/g resin） LXSS10-1-1401 100-200; 200-400 0.2-0.4 LXSS10-1-1402 100-200; 200-400 0.4-0.6 LXSS10-1-1403 100-200; 200-400 0.6-0.8

4-(2',4'-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-MBHA resin This   rink amide mbha resin  comprises the modified Rink amide linker attached to MBHA resin, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage fro this rink amide mbha   can be effected by single step treatment with 95% TFA, providing peptide amides in high yields and purities. Product No. Particle size （mesh） Loading （mmol/g resin） LXSS09-1-1201 100-200; 200-400 0.3-0.6 LXSS09-1-1202 100-200; 200-400 0.6-0.8 LXSS09-1-1203 100-200; 200-400 0.8-1.0