Seplite

The Fmoc method is a new method for solid phase synthesis of peptides developed by Carpino and Hart based on the Boc method. The fundamental difference between the Fmoc  ltd   /t-Bu(9-fluorenylmethoxycarbonyl/tert-butoxy) strategy and the Boc/Bzl strategy is the use of alkali-removable Fmoc is a protecting group for α-amino group, the side chain is protected by t-Bu which can be removed by TFA, and the solid phase carrier Wang resin with acid-sensitive linking arm is used, and the final step of the synthesis is removed by TFA. Han Xiang et al. successfully synthesized the 32-peptide thymosin α 1 by Fm oc solid phase method, starting from Fm oc-Asn(Trt)-W angResin, Boc protecting the side chain amino group of Lys, and tert-butyl ester group (O-t-Bu Protecting the side chain carboxyl group of Asp and Glu, t -Bu protects the side chain hydroxyl group of Ser and Thr, and trityl group (Trt) protects the side chain amide group of Asn, and the total synthesis yield is 33.2%, and...

W hat is weak acid cation ? SEPLITE ® Weak Acid Cation Exchange Resin The acidic ion exchange resin  is the type of ion exchange resin with functional group of carboxylic acid group (-COOH) . They show weak acidity like acetic acid, having the ability to exchange with bases such as NaOH and weak acid salts such as NaHCO3. The weak acid cation exchange resins have two kinds of chemical structures, a methacrylic acid type and an acrylic acid type. This makes a difference for the ion exchange ability. The methacrylic acid type can be used at pH above 5, while the acrylic acid type can be used at pH above 4. Even though use is restricted, it is easier to regenerate than a strong acid cation exchange resin. W eak acid cation resins  are suitable in the fields of removal of water dealkalization, carbonate hardness, purification of antibiotics and amion acid. It is not used much for water processing because of the less acidity, but for antibiotic and amino acid purif...

SEPLITE ® Strong Base Anion Exchange Resin The Strong Base Anion Exchange Resin  ( sba resin )  is the type of ion exchange resin with functional group of quaternary ammonium, which is strongly alkaline and dissociates just like NaOH and KOH. In chemical structure, there are two types of strong base anion exchange resin with different alkalinity strengths, Type Ⅰ with a trimethyl ammonium group, Type Ⅱ with a dimethylethanol ammonium group. Type Ⅰ shows a higher alkaline than Type Ⅱ. Compared with type 1 strong base anion, this resin is more suitable for applications needing good rinsing performance and excellent regeneration efficiency. The strong base anion    shows an excellent physical and chemical stability, which is capable of exchanging the different anion under a wide range of pH. The Strong Base Anion Exchange Resin is mainly used in water treatment, to produce high purity demineralized water, making use of the ability to adsorb anions stron...

SEPLITE ® Strong Acid Cation Exchange Resin The strongly acidic ion exchange resin  is the type of ion exchange resin with functional group of sulfonic acid The Strong Acid Cation Exchange Resins have two types, the gel and the macroporous type. The macroporous strong acid cation exchange resin shows an excellent dynamic characteristics. The gel type has excellent properties for industrial water softening and demineralization application. It has standard crosslinkage, which is usually used in mixed bed; the higher crosslinkage resin shows a longer operating life, and used in regenerable mixed bed. The Strong Acid Cation Exchange Resin shows an excellent physical and chemical stability, which operates at any pH(0-14), and are relatively stable to temperture, even in high temperatures of 100-120℃. The Strong Acid Cation Exchange Resin is applied in a wide variety of fields including water purification, water softening, waste water treatment, purification of pharmaceu...

Separation Technique Based on Ion Exchange & Adsorption Stevioside is mainly extracted from the roots and leaves of stevia leaves, with the highest content of stevioside in leaves. Its sweet taste mainly consists of stevioside A, B, C, D, E. Stevioside can be extracted with water, and after clarification and crystallization, extracts of different purities can be obtained. Stevioside is 250-450 times sweeter than sucrose, but because of the presence of stevioside A, it has a distinct bitter taste and astringency. Our stevioside extraction and purification   technology is based on the principle of ion exchange and adsorption, using a series supporting separation system to achieve extraction, decolorization, demineralization, purification and other important steps. Our technology has achieved great success in China. Sunresin has conducted in-depth research in the field of stevia refining. Sunresin once hosted the China Stevia Industry Technical Exchange Conference...

4-Hydroxymethyl-phenylacetamidomethyl resin PAM resin has become the most widely used resin in Boc chemistry peptide synthesis. It has greater acid stability than Merrifield resin, making it suitable for synthesizing medium and large peptides, such as DNA binding polyamines, human matrix Gla protein(MGP), Kappa-casein. The first carboxylic acid is attached to PAM resin  using an activating agent such as DCC and DMAP. These conditions can lead to partial epimerization of the amino acids, so HOBt is normally added to reduce racemization. Product No Particle size （mesh） Loading （mmol/g resin） LXSS11-1-1401 100-200; 200-400 0.4-0.8 LXSS11-1-1402 100-200; 200-400 0.8-1.2

SEPLITE ® Weak Base Anion Resin The Weak Base Anion Exchange Resin with primary, secondary, tertiary amine or mixed amine group as active functional groups show different strengths of alkalinity. Most weak Base Anion Exchange Resins with mixed amine group equiped a extremely high operating capacity with the ability to remove both strong and weak acids from solution. There are two kinds of weak base anion exchange resins, Gel type and Macroporous type, which have acrylic backbone, styrene backbone or mixed backbone. Weak base anion exchange resins are more chemically stable and higher resistant to organic fouling than strong base anions. The weak base anion exchange resin  is easier to regenerate than the strong base resin, and can be efficiently regenerated with a small amount of sodium hydroxide. Weak base anion exchange resins are commonly used in pharmaceutical, food engineering, and chemical engineering, such as the removal of mineral acid, organic acids and ot...